Opioid Withdrawal: Powerful Insights on Symptoms & Treatment
Opiate withdrawal is a life-threatening condition resulting from drug dependence. Opiates refer specifically to drugs derived directly from the opium poppy, such as morphine and codeine. However, the distinction between opioids and opiates is becoming less relevant as synthetic opioids become more common and natural opiates are synthesized into semi-synthetic opioids. Read more about opiate detox and the benefits of getting professional medical help.
Clinically Reviewed by Lauren Barry, LMFT, MCAP, QS
Medically Reviewed by Ali Nikbakht, PsyD
Reviewed / Updated: September 24, 2025 — Editorial Policy | Research Policy | Privacy Policy
By We Level Up | Author Alex Evans, PharmD, MBA | Editorial Policy | Research Policy
What are Opioids?
Opioids are a class of drugs that include prescribed pain relievers, such as oxycodone and morphine, and illegal drugs, such as heroin. However, opioids can be highly addictive. When people use opioids for a long time, they become physically dependent on the drug.
Unfortunately, the opioid crisis has had a devastating impact in the US. For those trying to break free from opioid dependency, withdrawal is often the first challenge, and without proper care, it can cause relapse.
Opioid withdrawal happens when someone stops using opioids. Their body goes through a period of adjustment that may cause uncomfortable physical and emotional symptoms. They may experience restlessness, heavy sweating, trouble sleeping, and digestive problems. Severe symptoms may require hospitalization. Luckily, there are several treatment options available to manage withdrawal symptoms.
In this article, we’ll cover the withdrawal symptoms, timeline, and treatment options available for opioid withdrawal.
Opioid Key Takeaways
- Opioid withdrawal occurs when you stop or significantly reduce opioid use after developing physical dependence.
- Withdrawal symptoms typically begin within 12-24 hours after the last dose, peak in intensity during the first few days, and subside within 7-10 days. Psychological symptoms may persist for weeks or months.
- Treatment options for opioid withdrawal include medical detox, medications like methadone and buprenorphine, behavioral therapies, and support groups.
- After completing detox, ongoing treatment and support are essential for maintaining long-term recovery and preventing relapse.
What is Opioid Withdrawal?
Opioids are a class of drugs that include prescribed medications such as oxycodone, hydrocodone, and morphine, as well as illicit substances like heroin. These drugs interact with the opioid receptors in your brain to block pain signals. They can also cause your brain to release dopamine, a chemical that makes you feel good. If you use them as directed by a doctor, prescription opioids are usually safe for a short period.
However, the prolonged use of opioids can make your body adapt to the presence of the drug. It may lead to physical or psychological dependence, or what we can call opioid addiction.
Physical dependence on opioids can develop quickly. Certain factors can influence your likelihood of developing opioid dependence and opioid use disorder, such as genetics, environment, mental health, how long you’ve been taking the drugs, and how much.
When you suddenly stop using opioid drugs on your own, it can affect you in many ways. While not typically life-threatening, your body may experience a range of withdrawal symptoms that can be very uncomfortable. The discomfort of withdrawal symptoms may drive you to continue using opioids to avoid or alleviate these symptoms.
One thing that can help you during this withdrawal process is proper care and discussion with your healthcare provider. They can help you understand how severe your withdrawal symptoms are. They will also create a treatment plan for you.
Symptoms of Opioid Withdrawal
Opioid withdrawal symptoms are generally divided into two stages: early and later.
How intense the symptoms are depends on:
- Type of opioid used
- How long you been using it?
- How long the drug stays in your body,
- Your health
- Whether you are quitting under the supervision of a healthcare provider

For short-acting opioids, like heroin, withdrawal can begin as soon as 4 hours after the last dose. They may include:
- Restlessness
- Anxiety
- Irritability
- Muscle aches and pains throughout your body
- Sweating
- Runny nose and watery eyes
- Yawning
- Insomnia
- Rapid breathing
These symptoms are shorter in duration and are more intense.
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Learn More:
- Opiate Withdrawal Symptoms, Can You Die From Opiate Withdrawal?
- How Long Do Opiates Stay in Your System, Body, Blood, and Urine?
- Opiate Addiction
- Opiate Withdrawal Restlessness
- Opioid Overdose Symptoms
- Opioid Withdrawal Symptoms
- Opioid Crisis
- Opioid Addiction Treatment
- Medical Detox Treatment
- Opioid Withdrawal Timeline
However, with long-acting opioids like methadone, withdrawal symptoms can appear within 72 hours after your last dose. They may include:
- Nausea and vomiting
- Diarrhea
- Abdominal cramps
- Goosebumps
- Dilated pupils
- Increased heart rate and blood pressure
In some cases, physical symptoms may disappear. However, psychological symptoms, like depression and cravings, can last for weeks or even months. This condition is known as post-acute withdrawal syndrome (PAWS).
Even though withdrawal symptoms are rarely life-threatening, they can be very uncomfortable and distressing.
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7/365 Line (844) 597-1011The Opioid Withdrawal Timeline
The timeline for opioid withdrawal varies from person to person. It also depends on the type of opioid used. Short-acting opioids like heroin may produce withdrawal symptoms sooner than long-acting opioids like methadone.
However, opioid withdrawal generally follows the following three stages:
Early Stage: Mild Symptoms Begin
A person’s craving for opioids typically begins after they miss a dose. Withdrawal symptoms can start as early as 4 hours after the last dose of short-acting opioids. For methadone, they may begin within 30 hours after the last dose.
During this stage, you may notice:
- Restlessness and irritability
- Muscle aches
- Trouble sleeping
- Light sensitivity
- Yawning
- Runny nose and watery eyes
Peak Stage: Intense Symptoms
As your body adjusts to not having opioids, withdrawal symptoms may get stronger and reach their highest point. With short-acting opioids, withdrawal symptoms often become severe within 1-3 days. For long-acting opioids and extended-release drugs, the peak may take longer after you stop taking opioids.
Common symptoms during this withdrawal phase are:
- Nausea, vomiting, and diarrhea
- Severe cravings for opioids
- Sweating and chills
- Flu-like symptoms such as fever, body aches, and fatigue
- Increased heart rate and blood pressure
- Mood changes, including depression, anxiety, or hopelessness
Last Stage: Gradual Improvement
For many people, physical withdrawal symptoms begin to gradually get better after 7-10 days. However, psychological symptoms like depression and cravings may persist. These lingering symptoms are often part of Post-Acute Withdrawal Syndrome (PAWS), which can last for weeks or months.
At this stage, support and treatment can help you avoid relapse. They can also address the reasons for opioid misuse, like anxiety, pain, or trauma.
What is the withdrawal timeline for different opioids?
Heroin: Withdrawal symptoms start within 12 hours after missing the last dose. They peak in 1-3 days and usually go away in 5-7 days.
Short-acting opioids (like hydrocodone, fentanyl, and oxycodone) cause symptoms to begin 8-24 hours after the last use. These symptoms get worse in 1-3 days and can last for 7-10 days.
Long-acting opioids (like extended-release drugs and methadone): Symptoms can take up to 36 hours to show. They peak at 72-96 hours and can last for 14 days or longer.

What Does Opiate Withdrawal Feel Like?
Opiate withdrawal symptoms can be both physical and psychological. You may have physical symptoms like nausea, vomiting, diarrhea, and stomach cramps. You might also feel muscle aches, have a runny nose, and experience chills, sweating, and goosebumps.
Opiate withdrawal yawning is common for people who are detoxing from opiates. During opiate use, opioids can slow down the brain’s normal breathing. This can lead to a lower breathing rate and less oxygen in the body. When a person stops using opioids, their body works to return to a normal breathing rate. This can lead to an increase in the rate and depth of breathing, which may also include yawning.
These symptoms are often accompanied by intense cravings for the drug, which can be difficult to resist and may lead to relapse.
Opiate Withdrawal Protocol Fact Sheet
Medical Detox From Opiates
Opiate withdrawal protocols are determined by the individual’s needs and the healthcare provider’s treatment approach. However, several general steps are typically included in an opiate withdrawal protocol, such as the following:
- Assessment: The first step in an opiate withdrawal plan is to check the person’s physical and mental health. This includes looking at any medical issues, past substance use, and mental health problems.
- Stabilization: After the assessment, the healthcare provider will help stabilize the person. This includes handling any urgent medical or mental health issues. They will also make sure the person is safe and comfortable.
- Medication-Assisted Treatment (MAT): MAT with opiate withdrawal medications, such as buprenorphine, methadone, or naltrexone, are often used. These medications reduce withdrawal symptoms and cravings and can be used in inpatient and outpatient settings.
- Behavioral Therapy and Counseling: Medication, behavioral therapy, and counseling are often part of an opiate withdrawal plan. They help people understand the reasons for their substance use disorder. These methods also teach skills to manage cravings and triggers.
- Follow-Up Care: After completing opiate withdrawal treatment, follow-up care is crucial for maintaining long-term recovery. This can include ongoing medication management, counseling, and support group meetings.
How Long Do Opioids Stay in Your System?
Opioids can stay in your body for a few hours to several hours after your last use. However, there are still many factors that determine how long opioids are detectable in your body. They may include:
- The type of opioid
- The amount of drug taken
- How it is taken (injecting or snorting)
- How your body processes it
Individual health factors like age, weight, hydration, and metabolism affect how long opioids can be detected. People with slow metabolism or liver and kidney problems may take longer to get rid of opioids. Chronic and heavy opioid use can also lead to accumulation in the body and so it can take longer to get rid of them. Lastly, different opioids work with your body’s receptors in a similar way. However, the time their effects last can vary.
Opioid testing is usually done by testing either urine or blood. How long opioids can be detected depend on the factors above. Heroin, for example, can be detected in a urine drug screening for around 2-3 days after last use.
Opiate Addiction
No matter what the narcotic is, ongoing use can lead to developing a physical dependency. When this occurs, the body has become so used to a sense that it often requires it to function. Psychological cravings usually follow shortly after that, resulting in what is known as full-blown addiction.
Using opiates greatly increases the risk of addiction. This is because they affect certain parts of the brain. Opioids activate our mu-receptors, which influence the sensations of both pain and pleasure.
Happiness is linked to reward pathways in the brain. When these pathways are activated, they create strong connections. This can quickly lead to compulsive behaviors. Opiates can create strong feelings that are up to 10 times more intense than the pleasure our bodies usually feel. Opioid highs feel like a “wave of euphoria.” They can be so strong that they change the brain, making it crave more after just one use.
In many cases, the abuse of opioid painkillers is not detected early enough to prevent a physical addiction. Sadly, many addicts taste their drug of choice (DOC) for the first time after they’ve been prescribed opioids by a doctor. Typically, younger people have become addicted to opiates due to injuries sustained by playing competitive sports, automobile accidents, etc. This particular addiction leads to hazardous behaviors. Social pressure and other illicit drugs can also lead to the abuse of illegal opioids.
Some signs of severe opiate addiction or the use of illicitly made opioids include the following:
- Withdrawal from everyday activities.
- Possession of drug paraphernalia (mental spoon, glass pipe, syringe, lighter, candle & matches).
- Doctor shopping. (going to multiple doctors to receive prescriptions)
- Going to numerous pharmacies around town to fill prescriptions.
Opiate Addiction Recovery Statistics
The CDC reports that opioid-related deaths have greatly increased in the last ten years. In 2018, they made up almost 70% of drug overdoses. These numbers include illicit and prescription opioid drugs. But it has primarily been the latter that has driven the ongoing epidemic crisis in the United States. Many people are already dependent on these substances. They must deal with opioid and opiate detox, withdrawal, and rehab. This is necessary for them to recover and build a better life. Fortunately, we do recover.
91%
Analyses have reported alarming relapse rates with opiate abuse compared to other drugs. One study found that up to 91 percent of opiate addicts relapse. This suggests that the risk of relapse may be higher for opiate addiction than for other drug addictions.
Source: NCBI
9.3 Million
In 2020, 3.3 percent (about 9.3 million individuals) reported misusing prescription pain drugs in the past 12 months.
Source: NIDA
50%
People with opioid use disorder have a lower chance of dying when they get long-term treatment. This treatment can include buprenorphine or methadone. This is true compared to those who do not receive treatment. Therapy using agonist medication is linked with an estimated death reduction of approximately 50 percent among individuals with opioid addiction.
Source: NCBI
Top 5 Opioid Detox Studies with Insights
Here’s a patient-friendly chart of the top Opioid Detox studies/guidelines.
Here is a useful list of trusted Opioid Detox studies and guidance. You can use these in clinical copy, program pages, or treatment guides. Each row summarizes the impact of the evidence on treatment. It turns this information into useful tips for care teams and admissions scripts. Sources were selected based on their recency, rigor, and relevance to integrated treatment.
| Study | Treatment Implications | Insights for Patients |
|---|---|---|
| Opioid Detoxification: A Review of the Role of Buprenorphine View Study | Buprenorphine helps manage opioid withdrawal symptoms and reduces cravings, making it an ideal option for detox. | Patients will experience fewer withdrawal symptoms when using buprenorphine, making detox more tolerable. |
| A Randomized Trial of Buprenorphine for Opioid Detoxification View Resource | Buprenorphine has been shown to be effective for short-term detoxification by reducing withdrawal symptoms and cravings. | Patients should expect a smoother detox with less severe symptoms when using buprenorphine compared to other medications. |
| Short-Term Detoxification with Buprenorphine in Opioid Use Disorder Read Article | This study shows that buprenorphine is effective for rapid opioid detoxification without significant risks of relapse or overdose. | Patients going through rapid detox should expect a faster process with buprenorphine. However, they may still feel some cravings. |
| Detoxification and Maintenance with Methadone vs. Buprenorphine for Opioid Use Disorder Read Study | Buprenorphine and methadone have comparable effectiveness in detox, but buprenorphine has fewer side effects. | Patients considering detox should weigh their options, as buprenorphine offers a less risky withdrawal process compared to methadone. |
| Efficacy of Buprenorphine in Opioid Detoxification: A Double-Blind Study Read Review | Buprenorphine helps reduce opioid withdrawal symptoms while preventing the misuse potential of traditional detox medications. | Patients will experience a smoother, more gradual detox process with buprenorphine. |
Addiction To Prescription Opiates
The opioid epidemic exploded in the 90s and has gained more momentum in recent years. Thanks to modern technology, more accurate information is publicly available. Subsequently, people are somewhat more attentive to what doctors prescribe. Unfortunately, it does not take long to develop a dependence on them. If you notice any of these signs in your or a loved one’s use of prescription opioids, reach out to an addiction specialist. They can provide help.
Opiate addiction, or opioid use disorder, is a long-term condition. It involves the strong urge to use opioids. This happens even when it harms a person’s health, relationships, and other parts of their life. Opiates are a group of medicines. They include painkillers like oxycodone, hydrocodone, and morphine. Opiates also include illegal drugs like heroin. When taken in high doses or for a long time, opiates can cause physical dependence. This means the body gets used to the drug and needs it to work normally.
Signs of Opioid Addiction
It’s important to get professional help for opiate addiction. This condition is serious and can be life-threatening for you or someone you care about.
- Taking frequent doses or larger doses to feel the same effect.
- Inability to stop or control the use.
- Uncontrollable cravings.
- Failure to perform at work, school, or fulfill personal obligations.
- Continued use despite consequences that negatively impact your life.
- Isolating; Withdrawn from social situations.
- Inability to stop despite mental or physical health concerns.
- Opiate withdrawal symptoms.
Treatment Options For Opioid Withdrawal
Opioid addiction is a medical condition that changes how the brain and the body work. It is not something people can stop on their own. Overcoming opioid addiction is possible and often requires professional help and support.
Successful, lifelong treatment to stay opioid-free includes long-term medication, counselling, or behavioural therapies. With the right treatment, you can manage opioid withdrawal symptoms safely and begin long-lasting recovery.
Medical Detox for Opioid Withdrawal
Medically managed detoxification is often the first step in treating opioid addiction. It involves the removal of opioids from your body safely under medical supervision. Doctors and healthcare workers help make the withdrawal process safe and comfortable. This is especially important for those with severe dependencies or long-term use. Medical detox is often done in hospitals or treatment centres, but some can do it as outpatients.
Which medications are used for opioid withdrawal? For mild withdrawal symptoms, you can use over-the-counter medicines. Aspirin, ibuprofen, or acetaminophen (Tylenol) can help with pain or discomfort.
More severe withdrawal symptoms may require hospitalisation and other medications. In these cases, your doctors may prescribe several medications to help reduce the severity of withdrawal symptoms. Options include:
- Methadone: This long-acting opioid reduces cravings and withdrawal symptoms by activating opioid receptors without producing a high. It is often used for people with strong opioid addiction. It can be slowly reduced to help the body adjust.
- Buprenorphine: It is a partial opioid agonist that minimizes withdrawal effects. It helps reduce cravings and withdrawal symptoms and is often used in combination with naloxone (e.g., Suboxone).
- Naltrexone: It blocks opioid effects and helps prevent the high associated with relapse. It is usually started after detox is complete and can be part of ongoing treatment to prevent relapse.
These drugs bind to opioid receptors and reduce withdrawal symptoms without eliciting euphoria in people with opioid dependency.
Other supportive medications may include:
Clonidine for Opioid Withdrawal
Clonidine is used primarily in the inpatient setting. It can help reduce the intensity of withdrawal symptoms. Clonidine works by calming the nervous system and is often used in combination with other treatments. It is especially good at easing anxiety, restlessness, sweating, and muscle aches.
Benzodiazepines for Opioid Withdrawal
Benzodiazepines are not typically used for opioid withdrawal. But studies show that two out of five people seeking detox for opioid use disorder had used benzodiazepines in the prior month. These medications act as sedatives, calming the brain and nervous system, which may give them relief during withdrawal. Benzodiazepines can be dangerous when combined with opioids, and they are not approved for opioid withdrawal. It’s best to speak with your healthcare provider if you want to come off of opioids.
Cannabidiol for Opioid Withdrawal
Cannabidiol (CBD), a non-psychoactive compound in cannabis, shows promise in easing opioid withdrawal symptoms. Research suggests it may reduce anxiety, nausea, insomnia, and pain, making withdrawal more manageable. A 2021 study found that CBD could lower opioid cravings and even help reduce opioid use in individuals with chronic pain.
CBD has potential, but it is not approved for opioid withdrawal. More research is needed to confirm its safety, effectiveness, and best dosages. CBD can help with traditional treatments, but it should only be used with a doctor’s guidance. It should be part of a complete withdrawal and recovery plan.
Trazodone for Opioid Withdrawal
Insomnia is one of the most common symptoms of opioid detox and withdrawal. Trazodone is often prescribed to help people with insomnia, and it may be used to help you get some sleep. It is usually taken at bedtime to minimize daytime drowsiness. Trazodone is considered safe and effective but should only be used as prescribed.
Vitamin C for Opioid Withdrawal
Vitamin C (ascorbic acid, AA) has been studied for its potential to reduce opioid consumption as well as help with withdrawal. However, it is not approved for either of these conditions. More research is needed to determine if it is safe or effective.
However, unlike other medications, it’s safe, affordable, and easy to find. Ask your healthcare provider first if it’s OK for you to take, but most people can add Vitamin C to their medication regimen.
Gabapentin For Opioid Withdrawal
Gabapentin is an anticonvulsant medication commonly used to treat nerve pain and seizures. Like Vitamin C, gabapentin has been studied as a potential treatment for opioid withdrawal. But more research is needed first. Gabapentin is a prescription medication and should only be used as instructed by your healthcare provider.
Kratom for Opioid Withdrawal
Kratom is an herbal extract from the leaves of a tropical tree native to Southeast Asia. In Asia, people use kratom in small amounts to reduce tiredness or attempt to self-treat opioid withdrawal.
However, kratom is not FDA-approved and can cause side effects. While researchers have studied kratom for managing withdrawal symptoms, the evidence shows that it may not help with addiction. Instead, using kratom could lead to dependency and withdrawal symptoms of its own.
Inpatient Rehabilitation
Inpatient facilities provide 24/7 medical and psychological care. These programs are ideal for people with severe addiction or co-occurring mental health disorders. They provide structured schedules, group therapy, and access to medical care.
Outpatient Programs
Outpatient programs allow you to receive treatment along with your daily tasks. These programs are for those with milder opioid dependence. They may include counselling sessions, medication management, and support groups.
Counselling and Therapy
Behavioural therapies and counselling address the psychological aspects of opioid addiction. They help people understand the reasons for opioid use disorder (OUD). They also teach skills to handle triggers and manage cravings. These approaches include:
- Cognitive Behavioral Therapy (CBT)
- Motivational Interviewing (MI)
- Contingency Management (i.e., provides incentives for maintaining sobriety, such as vouchers or prizes for negative drug tests)
Support Groups
Several groups, like Narcotics Anonymous (NA) or SMART Recovery, offer a community-based approach. These groups introduce you to people who have firsthand experience with what you’re going through. They can share recovery tips and support you in overcoming challenges.
Opioid Detox at Home
It’s best to only attempt opioid detoxification under medical care. Many people can stay at home during detox. Your healthcare team can help ease withdrawal symptoms. They will work with you to create a long-term plan to overcome opioid addiction.
If you are doing opioid detox at home, gather some supplies. You will need over-the-counter painkillers like aspirin, ibuprofen, or acetaminophen. Also, get anti-diarrhoea medicine, such as Loperamide (Imodium). Finally, have electrolyte drinks to help you stay hydrated.
Along with medications, some home remedies can help with withdrawal. Staying hydrated, getting enough rest, and eating a balanced diet are important. Light activities like stretching or walking can also help you relax and reduce stress. If you experience severe symptoms like rapid heartbeat, high fever, or hallucinations, seek immediate medical attention.
Remember, home detox carries risks such as dehydration, electrolyte imbalance, and relapse. It is important to have family or friends for support. They can help you know when to get medical help if things become hard to manage.
Once detox is over, keep up the recovery with therapy, support groups, and taking care of your mental health. Detoxing at home can be challenging, but with the right help, you can make it possible. If the withdrawal process gets too hard, don’t hesitate to reach out for professional help. Your health and safety are the top priority. Recovery is possible, and you have the strength to overcome it.
Opiate Detox Centers Near Me
How to help with opiate withdrawal? Treatment programs for opioid addiction usually begin with “opiates detox.” This is followed by inpatient treatment or other specific programs, like partial hospitalization or focused treatment. Only a finely managed treatment facility provides a controlled and comfortable setting to detox from opiates. Drug detox can happen with support and medications. These help reduce complications and problems linked to opiate withdrawal.
If you need help with opiate detox in Florida, Orange County, or Los Angeles, contact We Level Up. They have a nationwide helpline with resources and options near you. Opiate detox at a medical facility can reduce the severity of symptoms. This makes the withdrawal process easier and more comfortable. Our facilities provide different levels of treatment. This makes it easier to transition after finishing an opiate detox program.
We Level Up offers great amenities. These include semi-private rooms and luxurious bathrooms. There are also spacious common areas for socializing. You will find a communal dining area stocked with healthy snacks and more!
Opiate Detox Process
The opiate detox process is not the same as detoxing from other addictive substances, such as alcohol or cocaine. Withdrawal symptoms vary. Medications are often used to reduce physical symptoms and prevent strong cravings during opioid detox. Detox from heroin, fentanyl, and prescription opioids is a carefully managed process. Often, the same or similar medications are used after detox.
Medications like Subutex and Suboxone are approved by the Food and Drug Administration (FDA) to treat opioid dependence. These new medications have opened up various opioid detox treatment methods. The opioid detox process will differ for individuals detoxing via medically assisted treatment versus abstinence.

Opiate Detox Medications
Medical opioid detox helps smooth withdrawal, reduce side effects, prevent serious complications, and lessen opioid cravings. Some of the most common opiate withdrawal shots and medications are the following:
- Buprenorphine: Prescribed to reduce the period it takes for opiate detoxification and assist an individual in upholding prolonged abstinence from opioids. The commonly used brand name of this substance is Subutex. Suboxone is a drug that includes both buprenorphine and Naloxone.
- Methadone: Relieves and reduces the unpleasant impact of withdrawal symptoms.
- Naltrexone: Blocks the effects of opioids and may be used to induce withdrawal. It does not let the opioid intake affect the individual. Therefore, it may also be used to avert future dependence and misuse.
- Clonidine: It can help reduce flu-like symptoms from opioid withdrawal. It also helps with other symptoms like anxiety and agitation that many people feel.
These prescriptions and supplements for opiate withdrawal offer a decent start toward recovery and help maintain long-term sobriety. However, detox must be followed with counseling, education, and awareness. Family, individual therapy, and support groups can aid an individual in stopping the use of drugs and continuing sobriety.
What Can I Expect From an Opioid Detox Center?
Overcoming opioid addiction isn’t easy, but a professional detox center can make the process smoother and faster. At a detox center, doctors, nurses, therapists, and addiction experts work together to help you at every step.
The detox process generally begins with an in-depth assessment. You’ll be asked about your drug use history, how long you’ve been using it, how often, and in what amounts. This information helps your doctor to create a treatment plan according to your needs.
In a detox program, you’ll have 24/7 medical care to help manage withdrawal symptoms, which can last up to two weeks. Medical staff may use medications to ease discomfort, reduce cravings, and prevent complications. They may prescribe methadone, buprenorphine, or naltrexone to manage cravings and reduce relapse risk. Behavioral therapies, such as cognitive-behavioral therapy (CBT), are often integrated into the detox process.
Detox centers offer a supportive space. They take care of your daily needs, like meals and medication schedules.
Detox focuses on the physical aspects of withdrawal. Many detox centers also offer emotional support through counseling or therapy. To make detox more manageable, consider bringing activities to keep your mind occupied, such as crafts, books, or journals. These small comforts can help you stay distracted from withdrawal symptoms and feel more at ease.
Detox is the first step in recovery. Before you leave, the staff will help you plan your next treatment steps. This may include inpatient rehab, outpatient therapy, or support groups. They want to make sure you keep making progress. A smooth transition from detox to further treatment is essential for long-term recovery.
Contact us today to learn more about medically supervised detoxification treatment.
What Happens After Opiate Detox?
We Level Up offers several different levels of care for clients to enter after completing their opiate detox programs. Each of these programs offers treatment methods based on research. Studies over many years show these methods help people overcome opiate addiction.
Residential Treatment
Most clients will enter residential treatment after completing an opiate detox program. Residential treatment is the most intense drug and alcohol therapy option. Clients live on-site at a treatment center with others who are also working on recovery.
During the day, clients go to different therapies and groups. These are meant to help them overcome opiate addiction. They include these evidence-based treatments:
- Individual therapy.
- Group therapy.
- Relapse prevention programs.
- Motivational interviewing.
- Medication-assisted treatment.
- Family therapy.

Dual-Diagnosis Treatment
Dual-diagnosis treatment is designed to help people dealing with addiction and mental illness. Mental health issues like depression, panic attacks, anxiety, and PTSD are common in people with opiate addictions. They can be a serious roadblock on the path to recovery if left untreated.
These mental health disorders can happen before someone starts using substances. They can also develop after months or years of addiction. Whatever the case, a dual-diagnosis treatment facility can help. In a dual-diagnosis program, effective mental health treatment is integrated with evidence-based treatment for substance use disorders. This could include treatments such as:
- Psychiatric evaluations.
- Medication management.
- Cognitive-behavioral therapy.
- Eye movement desensitization and reprocessing.
- Dialectical behavior therapy.
A dual-diagnosis program offers these therapies alongside all the treatments for substance use disorders. Untreated mental health challenges can drastically increase the risk of relapse after leaving an intensive program. Dual-diagnosis treatment offers an additional defense against relapse by treating mental illness and addiction symptoms simultaneously.
Many people can achieve remission from their mental health concerns with targeted treatment. People who do not reach total remission can still see a big drop in symptoms. This change might be enough to help them stay sober for a long time.
Opiate Detox Treatment
Opioid addiction is a deadly, life-threatening disease that can have irreversible effects on one’s health and relationships. Without help, this addiction will more than likely turn deadly. You need immediate professional help and opiate detox. These are the only ways to avoid overdose risk and harm to yourself or someone you care about. Contact our treatment support at We Level Up to find the best treatment option.
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Types of Opioids / Opiates
There are many types of opioids in the U.S. Some are prescription drugs used to treat severe pain. Others are made illegally and misused. Learn more about some of the most common and dangerous opiate and opioid addictions:
What is Codeine?
Codeine is an opioid medication commonly used to treat pain and cough. Using codeine for a long time can lead to physical dependence and addiction. If you stop taking it, you may have withdrawal symptoms. Withdrawal from codeine can be uncomfortable, but it is usually not life-threatening. It is very important to get professional help when detoxing from codeine. Trying to detox alone can be dangerous and may cause complications or relapse.
Morphine Addiction
Morphine is a powerful opioid medication used to treat severe pain. It works by binding to the opioid receptors in the brain, blocking pain signals, and producing euphoria and relaxation. Morphine has a high potential for addiction and dependence, particularly with long-term use. Using morphine regularly can cause physical dependence. This means the body gets used to the drug. If someone stops taking it, they will have withdrawal symptoms.
Fentanyl Detox
Fentanyl is a potent synthetic opioid medicine used to treat severe pain. It is similar to other opioids like oxycodone and morphine but is significantly more potent. Fentanyl addiction can be hazardous, as the drug is powerful and can cause respiratory depression, overdose, and death. Treatment for fentanyl addiction typically involves a combination of medication-assisted treatment, counseling, and support groups. This may include medications to manage withdrawal symptoms and cravings and counseling to address the psychological aspects of addiction.
What is Hydrocodone?
Hydrocodone is a semi-synthetic opioid prescription drug for treating moderate to severe pain. It is obtainable in different forms, including tablets, capsules, and syrups. Hydrocodone is a Schedule 2 controlled substance in the U.S. This means it has a high risk of addiction and dependency.
Methadone Detox
Methadone is a long-acting opioid drug beneficial for treating opioid addiction and relieving severe pain. It is often used as a treatment for people with opioid addiction. It helps manage withdrawal symptoms and cravings. Methadone is an opioid. A methadone detox can help people stop using methadone safely. It also helps manage withdrawal symptoms.
Percocet Detox
Percocet is a prescription pain medication that combines oxycodone and acetaminophen. It is a powerful opioid that can lead to physical dependence and addiction with prolonged use. A medical detox program is often recommended for people dependent on Percocet. This involves a supervised withdrawal process in a safe and controlled setting, usually in a treatment center. During detox, patients may receive medications to manage their withdrawal symptoms and help them stay comfortable.
What is Oxycodone?
Oxycodone attaches to opioid receptors in the brain and spinal cord. This helps block pain signals and lowers the feeling of pain. It is often used with other pain relievers, such as ibuprofen and acetaminophen, to enhance its pain-relieving effects. Oxycodone can lead to drug addiction and dependence. It should only be used with close supervision from a healthcare provider. Patients must be watched carefully for signs of drug misuse, dependence, or addiction.
Dilaudid Detox
Dilaudid is a potent prescription opioid medication used to manage severe pain. Detoxing from Dilaudid can be hard and uncomfortable. Withdrawal symptoms can vary from mild to severe. Treatment for Dilaudid detox typically involves managing withdrawal symptoms and providing support to help individuals cope with the process. This may include medications to help with symptoms like anxiety, nausea, and pain. It may also involve counseling or support groups to address the mental aspects of addiction.
Heroin Detox
Heroin addiction can have many adverse effects on a person’s life. It can lead to financial, legal, relationship, and physical and mental health problems. Overdose is a big risk for people who are addicted to heroin. The drug can slow down breathing and may cause coma or death.
Treatment for heroin addiction typically involves a combination of medications and behavioral therapies. Certain drugs can support and manage withdrawal symptoms, reduce cravings, and avoid relapse. Behavioral treatments like cognitive-behavioral therapy, motivational interviewing, and contingency management can help people with heroin addiction. These methods teach coping skills, improve problem-solving, and help maintain abstinence from drug use.
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Frequently Asked Questions
Does alcohol help with opiate withdrawal?
No, alcohol can make withdrawal worse. It can cause dehydration and interact dangerously with detox medications. Do not ever attempt to treat opioid withdrawal with alcohol.
Does Suboxone help with opiate withdrawal?
Yes, Suboxone (buprenorphine/naloxone) reduces cravings and discomfort by acting on opioid receptors. It is used in medication-assisted treatment (MAT) programs under medical supervision to support long-term recovery.
Can you take ketamine for opiate withdrawal?
Ketamine, an anesthetic and pain reliever, is not a standard treatment for opioid withdrawal. It is also a prescription medication that should only be used under the supervision of your healthcare provider.
Is Lyrica effective for opiate withdrawal?
Lyrica (pregabalin) is an anticonvulsant and pain medication. It may help with anxiety and insomnia, but it isn’t approved for opioid withdrawal. It also carries its own risks of dependence and is a controlled substance.
Is hydroxyzine used for opiate withdrawal?
Hydroxyzine is an antihistamine with sedative properties. It may help with anxiety and sleep issues, but doesn’t directly treat withdrawal symptoms. Your doctor can decide if hydroxyzine is a good choice for your withdrawal management plan.
Is tramadol used for opiate withdrawal?
Tramadol is a prescription opioid that is not used for opioid withdrawal. It is also a controlled substance and has a risk of dependence and abuse. Do not use tramadol unless directed by your healthcare provider.
Is baclofen effective for opiate withdrawal?
Baclofen is a muscle relaxant not typically used for opioid withdrawal. It is also a prescription-only medication. Do not use baclofen unless your healthcare provider prescribes it for you.
Are detox drinks for opiates enough?
No, detox drinks are not enough to manage opioid withdrawal effectively. They can help with hydration and provide nutrients. However, they do not solve the serious physical and mental symptoms of withdrawal. These products often make unsubstantiated claims and are expensive. Talk to your healthcare provider before using any detox drinks.
What is opiate rapid detox?
This controversial approach uses anesthesia to speed up withdrawal. It may shorten the time of acute withdrawal. However, it has serious risks and does not help with long-term recovery. Healthcare experts generally recommend a more gradual detox for safer, more sustainable results.
Can you take loperamide for opiate withdrawal?
Loperamide can help with diarrhea, but it does not address other aspects of opioid withdrawal. It’s best to speak with your healthcare provider before using any OTC or prescription medications, including loperamide.
How Long Do Opiates Stay in Your System? How Long Do Opiates Stay in Urine, Blood, & Body?
How Long Do Opiates Stay in Your System? Brief Video Transcript.
Drugs in the opioid class are used to treat pain. Natural opioids, semi-synthetic opioids made from natural opioids, and synthetic opioids created in a lab are all called opioids. A class of medications known as opioids contains opiates, which are organic byproducts of the poppy plant. The main difference is that “opiate” refers to the substances derived from the opium (poppy) plant. At the same time, “opioids” are all substances that interact with opioid receptors, including those created in the lab.
The length of time that opiates remain in your system varies depending on the type of opiate, the dosage, and the frequency of use. Generally, opiates can stay in your system for two to four days. However, heavier and chronic users may have residues in their system for up to seven days.
Opiates can be detected in the blood test for up to 24 hours and in the urine test for up to three days. Opiates can be detected in the hair follicles for up to 90 days. In chronic users, opiates can stay in the body for up to 30 days.
Opiates often have short half-lives, meaning their effects can linger for several hours even though they swiftly leave the body. Opioids can stay in a person’s bloodstream for hours or days after symptoms go away. This depends on the type of substance used. Urine tests are a common way to check for drug use. They can find opioids in the body for three to four days. Some tests can even detect opioid use for up to three months.
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Search We Level Up Opiate Detox, Mental Health Topics & Resources
Resources
Fentanyl Detox – Explains detox for fentanyl, one of the strongest opioids. This connects to opioid withdrawal because fentanyl withdrawal symptoms are often more severe and require strict medical supervision.
Percocet Withdrawal Symptoms – Details specific symptoms and timelines for Percocet, a prescription opioid. This connects directly since Percocet withdrawal falls under the broader opioid withdrawal category.
Heroin Detox – Outlines heroin withdrawal timelines, symptoms, and treatments. Since heroin is a short-acting opioid, this link helps readers compare different opioid withdrawal experiences.
Methadone Detox – Describes detox from methadone, a long-acting opioid. This connects by showing how withdrawal symptoms and duration differ across opioid types.
Sources
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[3] Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings. Geneva: World Health Organization; 2009. 4, Withdrawal Management. Available from: https://www.ncbi.nlm.nih.gov/books/NBK310652/
[4] Institute of Medicine (US) Committee on Opportunities in Drug Abuse Research. Pathways of Addiction: Opportunities in Drug Abuse Research. Washington (DC): National Academies Press (US); 1996. B, Drug Abuse Research in Historical Perspective. Available from: https://www.ncbi.nlm.nih.gov/books/NBK232965/
[5] Opiate and opioid withdrawal – U.S. Department of Health and Human Services National Institutes of Health. Available from: https://medlineplus.gov/ency/article/000949.htm
[6] Prescription Opioids DrugFacts – National Institute on Drug Abuse (NIDA)
[7] Understanding the Opioid Overdose Epidemic – Centers for Disease Control and Prevention (CDC)
[8] Schiller EY, Goyal A, Mechanic OJ. Opioid Overdose. [Updated 2022 Sep 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470415/
[9] Narcotics (Opioids) – Drug Enforcement Administration (DEA)
[10] Risk Factors for Opioid Misuse, Addiction, and Overdose – U.S. Department of Labor


